Scientists have long been growing cells in natural and synthetic matrix environments to elicit phenotypes that are not expressed on conventionally rigid substrates. Unfortunately, growing cells either on or within soft matrices can be an expensive, labor intensive, and impractical undertaking.
Softwell overcomes these challenges. It enables you to study cell behaviors in soft environments with unprecedented efficiency. Furthermore, it provides control over matrix stiffness, a concept that has led to discoveries across a variety of cell types:
Remarkably, cells have the ability to sense and respond to changes in matrix stiffness. You can watch this happen in real time in our award-winning movie, Mechanosensing.
Tuning matrix stiffness offers a powerful approach to controlling stem cell fate. Simply culturing them on the proper stiffness has been shown to:
Just like the body’s tissues, Softwell is soft and deformable. These physical cues are entirely missed on a rigid Petri dish.
Softwell was created to revolve around your life at the benchtop - not the other way around. That’s because the hydrogels are:
Wash away unbound detection molecules and perform cell-based assays with minimal interference from the hydrogel.
The hydrogels are optically clear and compatible with most types of microscopic imaging.
Bound to the well
Aspirate, flick, or shake. Trypsinize, passage, and culture cells as long as you’d like. With a gentle touch, you can even scrape cells off the surface.
Cells are restricted to the hydrogel surface, making them readily accessible for isolation and analysis.